Secrets of a Secretin
نویسندگان
چکیده
منابع مشابه
Molecular evolution of GPCRs: Secretin/secretin receptors.
In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs. Despite being the first hormone discovered, secretin's evolutionary origin remains enigmatic, ...
متن کاملDifferent actions of secretin and Gly-extended secretin predict secretin receptor subtypes.
Only one secretin receptor has been cloned and its properties characterized in native and transfected cells. To test the hypothesis that stimulatory and inhibitory effects of secretin are mediated by different secretin receptor subtypes, pancreatic and gastric secretory responses to secretin and secretin-Gly were determined in rats. Pancreatic fluid secretion was increased equipotently by secre...
متن کاملModulation of secretin release by neuropeptides in secretin-producing cells.
Nerve fibers containing bombesin (BB)/gastrin-releasing polypeptide (GRP), pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), or galanin are known to innervate the mucosa of the upper small intestine. Both BB/GRP and PACAP have been shown to elicit secretin secretion in vivo. We studied whether the above-mentioned neuropeptides can act directly ...
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We propose an electronic market system for private data that guarantees levels of privacy, anonymity and control to individuals while maintaining the ability of other entities to mine their information and automatically pay individuals for their data. We also describe a novel procedure that allows data miners to anonymously contact the creators of the information in case their profiles are need...
متن کاملMechanism of acid-induced release of secretin in rats. Presence of a secretin-releasing peptide.
In fasting rats, intraduodenal infusion of dilute hydrochloric acid results in significant increases in both pancreatic exocrine secretion and plasma concentration of secretin. To test the hypothesis that acid-induced release of secretin is mediated by a secretin-releasing factor (S-RF), anesthetized rats were prepared with pyloric ligation, duodenal and jejunal cannulas, and pancreatic duct ca...
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ژورنال
عنوان ژورنال: Structure
سال: 2013
ISSN: 0969-2126
DOI: 10.1016/j.str.2013.11.002